Controlled release systems for tissue engineering

Electroactive polymers for controlled drug release –

We have developed several systems based on electroactive polymers for controlled, on-demand drug release. Through the use of polypyrrole and chondroitin sulfate, we have shown the ability to release a variety of molecules including several anionic drugs and cationic proteins.

SEM image of a PPy film containing DEX, deposited onto the controlled release electrode. 50 μm
SEM image of a PPy film containing DEX, deposited onto the controlled release electrode. 50 μm

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Electrospun nanofibers covering the polypyrrole layer.
Electrospun nanofibers covering the polypyrrole layer.

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Close up of the polypyrrole layer.
Close up of the polypyrrole layer.

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SEM image of a PPy film containing DEX, deposited onto the controlled release electrode. 50 μm
SEM image of a PPy film containing DEX, deposited onto the controlled release electrode. 50 μm

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Cage-like structures were patterned within scaffolds and accommodated PLGA microparticulate systems.
Cage-like structures were patterned within scaffolds and accommodated PLGA microparticulate systems.

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Mature blood vessels populated tissue construct with the sustained VEGF-release. Pink: alpha-SMA.
Mature blood vessels populated tissue construct with the sustained VEGF-release. Pink: alpha-SMA.

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Cage-like structures were patterned within scaffolds and accommodated PLGA microparticulate systems.
Cage-like structures were patterned within scaffolds and accommodated PLGA microparticulate systems.

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Integrating controlled release systems to 3D scaffolds – Through the integration of microparticles loaded with various molecules within 3D scaffolds, we can improve the outcome of engineered tissues after they have been implanted. For example, through the controlled release of the growth factor VEGF, vascularization within the tissue can be induced or through the release of anti-inflammatory agents, better integration within the host can be achieved.