Personalized regenerative medicine

Engineering diverse fully autologous tissue implants - We have developed a method to fabricate completely personalized implants where both the cells and the scaffolding material are generated from the same patient, and thus do not provoke an immune response that may lead to implant rejection. Our developed technology promotes efficient cell differentiation within a thermoresponsive hydrogel generated from the patient’s own tissue, and allows generating functional cardiac, cortical, spinal cord, dopaminergic and adipogenic tissue implants.

Stromal cells originated from human omental tissues were reprogrammed to become iPSC. 50 µm
Stromal cells originated from human omental tissues were reprogrammed to become iPSC. 50 µm

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Engineered iPSCs tissue. Blue: Ki67; green: OCT4
Engineered iPSCs tissue. Blue: Ki67; green: OCT4

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Spinal cord neurons TUJ
Spinal cord neurons TUJ

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Stromal cells originated from human omental tissues were reprogrammed to become iPSC. 50 µm
Stromal cells originated from human omental tissues were reprogrammed to become iPSC. 50 µm

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Digested dECM remains liquid at RT.
Digested dECM remains liquid at RT.

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Under physiological conditions, the digested dECM self-assembles into a structured hydrogel
Under physiological conditions, the digested dECM self-assembles into a structured hydrogel

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SEM image of the personalized hydrogel ultrastructural morphology
SEM image of the personalized hydrogel ultrastructural morphology

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Digested dECM remains liquid at RT.
Digested dECM remains liquid at RT.

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Omentum ECM-based hydrogel 

Our lab have developed an omentum-based hydrogel capable of self-assembly under physiological conditions. This is an ECM-based hydrogel, and as such is composed of a variety of biological molecules, such as collagens, proteoglycans, glycosaminoglycans and growth factors, providing the encapsulated cells with a biologically relevant microenvironment. The hydrogel can be used in various applications, like microfluidics and 3D bioprinting.